Title : Innovative approaches to impede the pathogens implicated in COPD exacerbation
Abstract:
Antimicrobial resistance is a significant global health issue. The prevalence and spread of antimicrobial-resistant organisms has been identified by the World Health Organization as one of the major healthcare challenges. Biofilms, communities of microorganisms largely resistant to antibiotics compound the antimicrobial-resistant challenge. Exacerbation of chronic obstructive pulmonary disease (COPD) is manifested by microbial infection. The objective of our research is to identify natural compounds that have antimicrobial activity and potential to mitigate COPD exacerbation. Several approaches using natural actives, bacteriocins, derived from commensal bacteria as well as actives isolated from plants show promise. We demonstrate eradication of respiratory biofilms and correspondingly enhanced efficacy of antibiotics on respiratory pathogens.
