The interferon (IFN) system is a cornerstone of host defense against viral infection, coordinating antiviral immunity while simultaneously shaping inflammatory responses. Although inflammation is required for effective viral control, excessive cytokine production underlies much o [....] » Read More
Health and social care systems around the world undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), considering the individual health status, conditions, genetic and genomic dispositions in personal, social, occupational, [....] » Read More
Background: Non Invasive Ventilation (NIV) is widely used in acute hypercapnic respiratory failure across diverse populations. Comorbid conditions as quantified by the Charlson Comorbidity Index (CCI) may influence NIV success and hospital outcomes. This study aims to evaluate pa [....] » Read More
Respiratory diseases represent a major and persistent public health challenge in the European Union, contributing substantially to morbidity, mortality, healthcare utilisation, and health inequalities. Despite existing initiatives, respiratory health remains insufficiently integr [....] » Read More
Lymphangiogenesis is an essential physiological process but also a determining factor in vascular-related pathological conditions. Angiopoietin-2 (Ang2) plays an important role in lymphatic vascular development and function and its upregulation has been reported in several vascul [....] » Read More
3D bioprinting has enormous potential for medicine. This new technology could significantly improve treatment of the lungs and lower respiratory tract by testing treatments on "organism-on-a-chip" biomodels of individual patients. Personalized respiratory medicine will [....] » Read More
Objective: To evaluate the clinical outcomes of Whole-Brain Radiotherapy (WBRT) in patients with Brain Metastases (BM) from lung adenocarcinoma who were not suitable candidates for stereotactic radiotherapy. Methods: The data of 53 patients who underwent WBRT between D [....] » Read More
At present, almost all countries are suffering with the deadly consequences of the SARS CoV-2 virus. Though ~80% among affected patients get recovered from this disease but patients suffering from comorbidities especially heart and lung diseases like, COPD (Chronic Obstructive Pu [....] » Read More
Respiratory diseases have become very common and the severity of the diseases has also increased in the present scenario of air pollution. Many of these diseases are linked to allergies and inflammations which are caused by the irritants present in in-door and out-door air surrou [....] » Read More
Diabetes is a chronic metabolic disease characterised by high blood sugar levels (HbA1c > 6.5%), resulting from the body’s in ability to produce or properly use insulin hormone which regulates blood glucose. It is characterized by 4 Ps-polyuria, polydipsia, polyphagia an [....] » Read More
Lung diseases [including chronic obstructive pulmonary disease (COPD), asthma, and lung cancer] are leading causes of death and chronic disability worldwide. Such health complications are often caused by (a) smoking, (b) infections, and (c) exposure to extreme air pollu [....] » Read More
Background: Periodontitis, a chronic inflammatory disease caused by complex interactions between host immune responses, bacterial infections, and environmental factors such as smoking, has been associated with various systemic diseases, including chronic obstructive pulmonary dis [....] » Read More
Intelligence has been an integral component of every aspect in all most all arenas of life. In the healthcare industry, the degree to which it has been impacted is comparatively low and the progress is in smaller steps when compared to those made in other fields. This can be attr [....] » Read More
The study presents a clinical reasoning and documentation framework for chest physical therapy techniques for pulmonary patients. The gap addresses a lack of confirmatory evidences or clinical care pathways, and a need to do the bedside analysis and creation of treatment plan for [....] » Read More
Background: Respiratory infection (RTI) is a viral spreading disease and it transmits from individual to individual, particularly in youngsters and aged peoples. The treatments are available but have so many limitations. To treat RTI, the phyto-constituent antibacterial drug cumi [....] » Read More
Introduction: Brugada syndrome (BrS) is an uncommon genetic disorder responsible for 4-12% SCDs due to ventricular fibrillation. Brugada phenocopy (BrP) is a category of clinically diverse entities causing identical Brugada-like electrocardiographic patterns to actual Brugada syn [....] » Read More
Public health and environmental security are seriously at risk due to the growing contamination of pathogenic microorganisms. Therefore, effective antimicrobials are urgently needed. In our study, the antimicrobial effects of three types of nanoparticles were investigated with ph [....] » Read More
Introduction: On June 10, 2021, the health district of Dianra notified the epidemiological surveillance service of the National Institute of Public Hygiene of four suspected cases of pulmonary tuberculosis residing in the village of Katiali located 7 km from the said district. [....] » Read More
Chronic Obstructive Pulmonary Disease (COPD) and Lung cancer are the major reasons for lung disease related mortality worldwide. Chronic inflammation is a key attribute of COPD and a potential driver of lung carcinogenesis. Among various environmental risk factors, cigarette smok [....] » Read More
Community acquired pneumonia is an important cause of morbidity and mortality in children as well as adults. Risk factors are anatomical deformities in lungs, exposure to dust and construction work, aspiration, smoking, genetic disorders like Cystic fibrosis and others. Bacteria [....] » Read More
Rationale and Aims of study: Recent surveys suggest that over 50% of adult asthmatics remain uncontrolled despite guideline-based standard therapy. As a potential cause SAD is often under-recognized as a major site of airway obstruction and inflammation related to the lack of ass [....] » Read More
Introduction: Lung transplantation remains a life-saving treatment for patients with end-stage lung disease however only 20% of donated lungs are suitable for transplantation. Ex Vivo Lung Perfusion (EVLP) enables rehabilitation of donor lungs but its closed-circuit design result [....] » Read More
Introduction: Every year thousands of patients with end stage lung disease await life saving lung transplantation yet only 20% of donated lungs are suitable for transplant. Ex Vivo Lung Perfusion (EVLP) allows for preservation before transplantation by ventilating and perfusing d [....] » Read More
Emotional breathlessness, an interplay of psychological distress and physical breathlessness remains critically under-recognised determinant of health in chronic respiratory disease(CRD). The recent Breath & Mind Survey (UK, October 2025) shows a clear public awareness gap in [....] » Read More
Introduction: Lung cancer is the leading cause of cancer mortality globally, with most cases diagnosed at advanced stages. In Latin America, limited access to structured screening makes AI-integrated diagnostic tools a pragmatic pathway for early detection. qXR (Qure.ai) is a CE- [....] » Read More
Background: LGBTQIA+ includes Lesbian, Gay, Bisexual, Transgender, Queer (or Questioning), Intersex, Asexual (or Aromantic/Agender), plus other diverse sexual orientations and gender identities (e.g., nonbinary, pansexual, two-spirit, gender-fluid, etc). Health inequiti [....] » Read More
Investigations are recorded for the Environmental Health Impact Assessment (EHIA) process for the pulmonary disorders and lung health, stomach health and dermal health (three axis) due to respirable suspended particulate matter less than ten microns in source specific, specific i [....] » Read More
Navigational bronchoscopy represents a paradigm shift in the diagnosis and management of peripheral pulmonary lesions. This minimally invasive technology guides endoscopic tools to pulmonary lesions with unprecedented precision, addressing a critical clinical need in contemporary [....] » Read More
The author of this research argues that respiratory nursing care is of upmost importance in overall health management. It gains increased significance in the present day world situation which is marked by increase in global warming-induced respiratory illness. It is for this reas [....] » Read More
Introduction: Pulmonary nodules detected on imaging frequently fail to translate into timely diagnoses due to fragmented and gaps in follow-ups. Even technically successful AI detection of lung nodules on imaging may be clinically redundant in the absence of structured and g [....] » Read More
Introduction: Non-small cell lung cancer (NSCLC) remains a biologically complex and therapeutically challenging disease, accounting for nearly 85% of lung cancer diagnoses worldwide. After decades of studying tumour systems biology, it has become increasingly evident that oncogen [....] » Read More
The ability of M. tuberculosis to respond to intramacrophage stresses such as oxygen/nitrogen radicals and low pH is important for its persistence. It has been reported earlier that an AraC/XylS type transcriptional regulator, VirS, is induced under low pH and regulates cell enve [....] » Read More
Rare interstitial lung diseases (ILDs) comprise a heterogeneous group of diffuse parenchymal disorders with overlapping clinical presentations, making diagnosis challenging. High-resolution computed tomography (HRCT) has become a central noninvasive tool for early detection and c [....] » Read More
Chronic diseases characterized by persistent oxidative stress such as cardiovascular disorders, type 2 diabetes, neurodegenerative diseases, and chronic obstructive pulmonary disease (COPD) share common pathogenic pathways, including sustained inflammation and redox imbalance. Ho [....] » Read More
Background: Pulmonary abscess is a rare but severe suppurative lung infection in the pediatric population. Typical clinical manifestations include fever, cough, productive sputum, and chest pain. The condition is often associated with a prolonged course and high morbidity, and [....] » Read More
Introduction: N-acetylcysteine (NAC) has mucolytic and antioxidant properties, resulting in wide clinical use. Thus, the working group reviewed the literature to reach a consensus regarding the use of NAC across the spectrum of indications. Materials and Methods: The working gro [....] » Read More
Background: Latent tuberculosis infection (LTBI) is a silent immune response to Mycobacterium tuberculosis without clinical symptoms but with potential for reactivation. Despite progress toward the WHO End TB Strategy, household contacts of tuberculosis (TB) patients remain [....] » Read More
Title : Changing population immunity to COVID-19 in the context of infection, vaccination and emerging SARS-CoV-2 variants
Ranjan Ramasamy, ID-FISH Technology, United States
The changing state of protective immunity to COVID-19 in the global population during the six and a half years since COVID-19’s origin in 2019 is analysed in the context of the (i) circulation of SARS-CoV-2 in the population, (ii) widespread use of different types of C [....] » Read More
Title : New mechanisms and innovative therapeutics for pulmonary hypertension
Yong Xiao Wang, Albany Medical College, United States
Pulmonary Hypertension (PH) is a common and serious lung disease, molecular mechanisms remain poorly understanded, and medications are neither always effective nor specific. In a series of our current studies, we have explored the potential important role of ryanodine receptor 2 [....] » Read More
Title : Innovative approaches to impede the pathogens implicated in COPD exacerbation
Zvi G Loewy, New York Medical College, United States
Antimicrobial resistance is a significant global health issue. The prevalence and spread of antimicrobial-resistant organisms has been identified by the World Health Organization as one of the major healthcare challenges. Biofilms, communities of microorganisms largely resistant [....] » Read More
Title : Missed, mistaken, but treatable: Refractory mycobacterium avium complex infection revealing anti interferon-γ autoantibody mediated immunodeficiency
Yazdan Mirzanejad, University of British Columbia, Canada
Neutralizing anti–interferon-gamma autoantibodies (anti–IFN-γ AAbs) are an underrecognized cause of adult-onset immunodeficiency associated with disseminated Non Tuberculous Mycobacterial (NTM) infections and frequent diagnostic delay. A 45-year-old woman with s [....] » Read More
Title : The needs of people with lung cancer: The role of patient organizations
Bernard Gaspar Martinez, AEACaP (Spanish Association of Lung Cancer Patients), Spain
The Spanish Association of Lung Cancer Patients is a national organisation whose role is to address the specific needs of people living with this disease. These needs go beyond purely medical considerations, particularly in terms of emotional, social, functional and financial sup [....] » Read More
Title : Syndromic surveillance of influenza based on sentinel pharmacies
Pedro Plans Rubio, College of Physicians of Barcelona, Spain
Influenza is responsible for seasonal epidemics every winter, with great impact on the health system. Community pharmacies are involved in the prevention and control of influenza and other diseases. In Catalonia, Spain, a new influenza surveillance system based on 60 community se [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through biodesign driven and inspired biotech, translational applications and pulmonology related marketing to secure the human healthcare, wellness and biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). To achieve the im-plementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the recogn [....] » Read More
Title : Susceptibility to SARS-CoV-2 infection and nasal air conditioning ability
Ranjan Ramasamy, ID-FISH Technology, United States
The nasal cavity has an important physiological role in warming and humidifying inspired air before the it enters the nasopharynx and trachea. This process has been termed nasal air conditioning. Nasal structures vary geographically, and have been correlated with the varying need [....] » Read More
Title : The role of PPARγ agonists in host defense
Brahmchetna Bedi, Emory University, United States
Pseudomonas aeruginosa is a major cause of multidrug-resistant infections, particularly in immunocompromised and hospitalized patients. Its pathogenicity is driven by quorum sensing (QS) molecules, such as N-(3-oxo-dodecanoyl)-L-homoserine lactone (3O-C12-HSL), which regulate vir [....] » Read More
Title : Matrix metalloproteinase-7 restricts RSV infection through cleavage of viral and host entry factors
Ihssan Kdah, Université de Reims Champagne Ardennes, France
Introduction & Aim: The airway epithelium constitutes the primary barrier against respiratory viral pathogens and actively shapes innate immune responses through the secretion of bioactive mediators. Among these, MMP-7 (matrilysin), a zinc-dependent endopeptidase constitutive [....] » Read More
Title : Micronutrient deficiency in cystic fibrosis
Marlene Fabiola Escobedo Monge, University of Valladolid, Spain
Cystic fibrosis (CF) is a genetic disorder caused by various mutations that primarily impact the respiratory and digestive systems and can necessitate the intake of micronutrients. This research was a cross-sectional study to investigate micronutrients in a group of CF patients. [....] » Read More
Title : The airflow channel as a regulator of overall health: The role of the upper airway, intermittent hypoxia (HIF), and the MFS approach in preventing respiratory dysfunction
Monika Osko, Orthodontic World Institute, University of Barcelona, Spain
The upper airway the “airflow channel” (nose, nasopharynx, and pharynx) is not merely a passive conduit. Breathing route (nasal vs. oral), nasal airway resistance, and nasopharyngeal mechanics influence ventilation quality and gas exchange both day and night, thereby [....] » Read More
Title : Menopause worsens donor lungs status after brain death
Luciana Coelho Marques, University of São Paulo Medical School, Brazil
Background: Lung transplantation is an established treatment for end-stage pulmonary diseases; however, organ scarcity remains a major limitation. The lung is particularly vulnerable to injury following brain death (BD), and evidence indicates that females may exhibit a heighte [....] » Read More
Title : The promise of nanotechnology in Personalized and Precision Pulmonology (PPP): Lung bioengineering and clinical translation in PPP guided practice
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
Despite breakthroughs in designed-driven research that have led to an increased understanding of PPM-based disease the translation of discoveries into therapies for pulmonary patients and pre-illness persons-at-risk has not kept pace with medical need. Biodesigners, bio-technolog [....] » Read More
Title : Personalized and Precision Oncology (PPO) to be set up via a precision oncology strategy for the cancer care team: Developing targeted lung cancer therapy and advancing personalized cancer care
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
Lung cancer is one of the leading causes of cancer death among both men and women making up almost 25% of all cancer deaths. A comprehensive molecular tumor analysis integrating a combination of NGS methods offers the best chance for personalizing cancer care, enlarging the scope [....] » Read More
Title : Unexpected pulmonary cryptococcosis in an immunocompetent individual: Case report and clinical analysis
Sergio Silvestre Soto Sanchez, University of Monterrey, Mexico
Pulmonary cryptococcosis in immunocompetent individuals represents an underestimated diagnostic and therapeutic challenge, with growing relevance in clinical practice and global public health. Although historically associated with advanced immunosuppression particularly HIV infec [....] » Read More
Title : Emerging burden of non-tuberculous mycobacteria in MGIT-based tuberculosis cultures: Insights from South India
Ambati Mrudula Srinivasulu, Yoda Diagnostics, India
Background: Non-Tuberculous Mycobacteria (NTM) are increasingly recognized as clinically significant pathogens that can mimic Mycobacterium Tuberculosis (MTB) in both clinical presentation and laboratory features. Because of intrinsic drug resistance and overlapping morpholo [....] » Read More
Title : Diagnostic values of FeNO and correlation between FeNO and FEV1 in asthma patients
Dae Sung Hyun, Daegu Catholic University Medical Center, Korea, Republic of
Background: The absence of airflow limitation in spirometry is common in asthma. The methacholine challenge test (MCT) is often necessary for the diagnosis of asthma, but it is usually performed in secondary or tertiary hospitals. Fraction exhaled nitric oxide (FeNO) is an e [....] » Read More
Title : Utilising diaphragm ultrasound to investigate correlation between skeletal muscle mass and diaphragm thickness
Yau Long Wong, Tung Wah College, Hong Kong
Diaphragm Ultrasound (DUS) has tremendous clinical value due to its non-invasive nature. Previous studies showed significant differences in diaphragm thickness between gender. However, the relationship between diaphragm thickness and skeletal muscle mass (SMM) has not been establ [....] » Read More
Title : Utilising diaphragm ultrasound to investigate correlation between skeletal muscle mass and diaphragm thickness
Cheuk Ying Lun, Tung Wah College, Hong Kong
Diaphragm Ultrasound (DUS) has tremendous clinical value due to its non-invasive nature. Previous studies showed significant differences in diaphragm thickness between gender. However, the relationship between diaphragm thickness and skeletal muscle mass (SMM) has not been establ [....] » Read More
Title : Utilising diaphragm ultrasound to investigate correlation between skeletal muscle mass and diaphragm thickness
Kin Hei Yu, Tung Wah College, Hong Kong
Diaphragm Ultrasound (DUS) has tremendous clinical value due to its non-invasive nature. Previous studies showed significant differences in diaphragm thickness between gender. However, the relationship between diaphragm thickness and skeletal muscle mass (SMM) has not been establ [....] » Read More
Title : Utilising diaphragm ultrasound to investigate correlation between skeletal muscle mass and diaphragm thickness
Cheuk Tung Au, Tung Wah College, Hong Kong
Diaphragm Ultrasound (DUS) has tremendous clinical value due to its non-invasive nature. Previous studies showed significant differences in diaphragm thickness between gender. However, the relationship between diaphragm thickness and skeletal muscle mass (SMM) has not been establ [....] » Read More
Title : Untargeted metabolomics of plasma and saliva: Insights into smoking associated COPD pathophysiology
Rishita Singh, Indian Institute of Science Education and Research- Kolkata, India
Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder characterized by airflow limitation, chronic inflammation, and loss of elastic recoil, leading to reduced forced expiratory volume (FEV) and impaired lung emptying during expiration. It is the third leadi [....] » Read More
Title : Respiratory and spirometric findings among individuals exposed to different residential radon levels in California, Santander
Cristian Ornandy Henao Nino, Universidad Industrial de Santander, Colombia
Introduction: Radon is a radioactive gas and a well-established risk factor for lung cancer. However, its association with respiratory symptoms and pulmonary functional abnormalities in populations with chronic environmental exposure remains incompletely characterized. In the mun [....] » Read More
Title : Chemical pleurodesis with povidone iodine in pneumothorax and methastatic pleural effusions
Samia Aissani, University of Algiers, Algeria
Introduction: Chronic or recurrent pneumothorax and metastatic pleurisy are serious problems. thez need to find a less invasive and inexpensive therapeutic means to create a symphysis. We report our experience in chemical pleurodesis with povidone iodine at 10% (betadine) during [....] » Read More
Title : Epidemiological profile of pulmonary tuberculosis in Kouto, Côte d’Ivoire, 2015–2024
Karamoko Mamadou, Ministry of Health/FETP Cote d'Ivoire, Cote d'Ivoire
Introduction: Côte d’Ivoire, like most sub-Saharan African countries, has a high incidence of tuberculosis. In 2023, it reported 21,458 cases with 1,717 deaths. The Kouto health district, in the Bagoué region, is no exception. However, tuberculosis data from th [....] » Read More