Title : Film scaffolds for tissue engineering in pulmonology, respiratory medicine and lung health
Abstract:
3D bioprinting has enormous potential for medicine. This new technology could significantly improve treatment of the lungs and lower respiratory tract by testing treatments on "organism-on-a-chip" biomodels of individual patients. Personalized respiratory medicine will become possible with the simultaneous testing of multiple treatment methods and drugs, identifying the most effective with minimal toxicity. In the future, it will be possible to manufacture not only patches, but also entire organs without rejection (bronchi, trachea). A biodegradable film material has been developed for the production of porous scaffolds similar to lattice structures for rapid 3D bioprinting with the ability to be laser perforated, with a hole size of ~60−100 μm and boundaries of ~20−45 μm respectively, ensuring almost 100% cell viability. Performance acceleration occurs due to the use of a ready-made scaffold without stereolithographic solidify and extrusion. Time is spent only on perforating holes for follicles, channels for transporting fluid, nutrients and oxygen to cells, instead of creating the entire scaffold layer. The created organoids unites the biocompatibility of hydrogels and the strength of polymers, using a combination of biodegradable framework materials. These films can be used not only for breakthrough Roll Porous Scaffold (RPS) 3D bioprinting technology with performance >1.7 L per hour at a layer thickness of 18 μm, but also to significantly accelerate the operation of traditional extrusion, laser and inkjet bioprinters.
