Title : Role of various viruses and their codon choices involved in causing lung cancer
Abstract:
At present, almost all countries are suffering with the deadly consequences of the SARS CoV-2 virus. Though ~80% among affected patients get recovered from this disease but patients suffering from comorbidities especially heart and lung diseases like, COPD (Chronic Obstructive Pulmonary Disease), asthma, lung cancer, etc. are at high risk of fatal consequences of the viral infection. As the disease COVID-19 caused by the SARS CoV-2 in such patients affect the airflow and increases inflammation in respiratory tract further leading to death. Other viruses like parainfluenza virus (PIV) and human metapneumo virus (HMPV) are minor pathogens like coronaviruses, also affect all age group including children suffering from asthma. These viruses are contagious and classified under the same family Paramyxoviridae. We performed computational study involving various CUB indices to understand the synonymous codon usage pattern and host adaptation of HMPV viral genome using the genome sequences available on NCBI. In this study, we have considered a total of 89 transcripts (HMPV) that are an exact multiple of three bases and having a start and stop codon without any unknown base (N) in the entire length of coding sequences. The nucleotide composition analysis of HMPV, depicted A and T preference over G and C at first and third codon positions. The RSCU analysis represented A/U ending codons preference over G/C ending codons in the viral genome. Codon adaptation index (CAI), RCDI and similarity index are the major parameters that reveals host relatedness, the present study showed strong host adaptation for Homo sapiens.
