Title : Preparation and characterization of nano-liposomal formulation for respiratory disorders
Abstract:
Respiratory diseases have become very common and the severity of the diseases has also increased in the present scenario of air pollution. Many of these diseases are linked to allergies and inflammations which are caused by the irritants present in in-door and out-door air surrounding us. As most of the current day’s medicines are linked with several side effects, scientists are currently looking for potential drug molecules from plants. India has a rich culture of plant-based medicines which are combinedly being studied and evaluated in AYUSH system these days. Though scientist have been able to identify potential drug candidates from these natural products the major problem associated with these molecules is that they are commonly known to have low bioavailability, shorter shelf life and easy biodegradability. Use of nanotechnology has been very beneficial to overcome these challenges. The current study was conducted to design nano-liposomal formulation from the plant Eucalyptus and Adhtoda vasica to overcome the disease ARDS (Adult Respiratory Distress Syndrome). The nanoliposome of size 70-200 nm were prepared, characterized and were evaluated for the safe dose range. Further it was found that they are able to overcome certain very important features which would help to normalize the respiratory process such as: surface tension inside the alveoli. inflammation and apoptosis. Present study describes the preparation, characterization and evolution of nano-liposomal formulations for respiratory disorders.
