Lung Microbiome & Host–Pathogen Interactions

Scientific interest in the lung microbiome & host–pathogen interactions has surged as studies reveal the lung is not sterile but hosts a dynamic microbial ecosystem. Disruptions in microbial balance are linked to asthma, COPD, and pulmonary fibrosis, while certain pathogens directly influence inflammatory responses and immune regulation. Metagenomic sequencing, 16S rRNA analysis, and spatial transcriptomics are key tools unraveling microbial communities in healthy and diseased lungs. Lung microbiome & host–pathogen Interactions explores how viral, bacterial, and fungal organisms interact with host immunity, modulating disease severity and treatment outcomes. Translational research in this space is driving interest in microbiome-targeted therapies, including probiotics, bacteriophage therapy, and microbiota transplantation. The challenge now lies in converting microbial insights into personalized, actionable interventions.