Disease heterogeneity, overlapping symptoms, and individualized responses demand precise management strategies across Obstructive Airway Diseases: COPD, Asthma, Bronchiectasis, CF. Each of these conditions involves distinct yet intersecting pathophysiological mechanisms, requiring tailored pharmacologic and non-pharmacologic interventions. Biomarker-guided therapies and biologics for eosinophilic asthma and cystic fibrosis modulators represent key breakthroughs. Obstructive Airway Diseases: COPD, Asthma, Bronchiectasis, CF also draws attention to airway microbiome research, exacerbation prediction models, and advances in mucolytic therapies. Multidimensional assessment tools are replacing one-size-fits-all approaches in diagnosis and prognosis. Environmental control, pulmonary rehabilitation, and structured patient education remain central to long-term management. Collaborative care and personalized medicine are reshaping how these chronic obstructive diseases are understood and treated.