The accumulation of fluid in the pleural space, known as pleural effusion, represents a common yet clinically diverse condition linked to heart failure, infections, malignancies, and autoimmune disorders. Accurate diagnosis is essential, as the underlying cause dictates prognosis and therapeutic strategy. Modern approaches to pleural effusion treatment begin with imaging and thoracentesis, allowing both symptom relief and fluid analysis to determine etiology. Management may be as straightforward as diuretic therapy in heart failure or as complex as pleurodesis or indwelling catheter placement in malignant effusions. In infectious causes such as empyema, prompt drainage combined with antimicrobial therapy is critical to prevent complications. Advances in ultrasound-guided procedures have increased safety and diagnostic yield, reducing reliance on more invasive approaches. Minimally invasive thoracoscopy provides opportunities for both biopsy and therapeutic intervention in uncertain cases. Alongside procedural care, attention to patient comfort, recurrence prevention, and long-term monitoring is vital. Recent research into biomarkers is enhancing differentiation between benign and malignant effusions, supporting earlier and more targeted interventions. By combining diagnostic precision, effective therapeutic options, and individualized patient care, pleural effusion treatment continues to advance toward better outcomes, improved quality of life, and reduced healthcare burden.
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